Bat soup anyone? Photo by Kevin Frayer/Getty Images)

The idea that SARS-CoV-2 was engineered in a laboratory, and then escaped accidentally, always had a certain plausibility. The virus first appeared in Wuhan, China, where there is a laboratory that conducts research on bat coronaviruses — one of only a handful in the world to do so. Yet this possibility was dismissed quite forcefully and from the beginning of the outbreak by prominent virologists.
Now that same lab-leak hypothesis appears to be on the verge of acceptance as the most likely. Such reversals happen; it is the nature of science. In an emergency, it is understandable that a research community might commit to one theory over another, even if prematurely, in order to focus its intellectual energies and resources. Surely that’s what happened here.
But there may be more to the story. On 2 May, the veteran science reporter Nicolas Wade published a long, detailed account of the career of the lab-leak hypothesis. His reporting appears to have triggered a cascade of defections, not simply from a consensus that no longer holds, but from a fake consensus that is no longer enforceable.
Now 18 scientists have signed a letter in the journal Science with the title “Investigate the origins of COVID-19”. The New York Times notes that “Many of the signers have not spoken out before.” “Speaking out” is an odd locution to use in a scientific context; one expects to find it in a story about a whistle blower. If, during the Covid fiasco, scientists have not felt free to speak their minds, then we have a serious problem that goes beyond the immediate emergency of the pandemic. Regardless of how the question of the virus’s origins is ultimately decided, we need to understand how the political drama surrounding the science played out if we are to learn anything from this pandemic and reduce the likelihood of future ones.
By now the reader will have heard of “gain of function” research and the hazards it poses. A large number of scientists came together in July 2014 as the Cambridge Working Group to urge that “Experiments involving the creation of potential pandemic pathogens should be curtailed until there has been a quantitative, objective and credible assessment of the risks, potential benefits, and opportunities for risk mitigation, as well as comparison against safer experimental approaches.” Later in 2014, the Obama administration issued a moratorium on this type of research, partly in response to some “bio-safety incidents” that occurred at federal research facilities.
But before the ban went into effect, the National Institute of Allergy and Infectious Diseases (NIAID) funded some gain-of-function research which, through an intermediary nonprofit and subcontracting arrangement, came to be conducted at the Wuhan Institute of Virology. The moratorium was lifted during the Trump administration, apparently at the urging of Anthony Fauci, and a 2019 renewal of the 2014 research grant did include gain-of-function research on bat coronaviruses. SARS-CoV-2 exhibits biological signatures consistent with the plan of research laid out in the grant.
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