Even Florida can't make you happy. Credit: John Greim/LightRocket via Getty Images

Was depression invented by the American elites in the Nineties? Since Prozac was introduced in 1987, it is true that the “major depressive disorder” — coined in the medical literature of the Eighties as a stop-gap measure — has taken remarkable hold.
When the first antidepressants were developed in the Fifties, the condition was considered so rare that the drug research seemed like a waste of money. But in a 2017 survey, 12.7% of Americans had taken antidepressants in the past month (and nearly twice as many women as men). It is not to deny the existence of catatonic states of despair to suggest that there may have been a definitional leak.
One might retort that “depression” was simply “under-diagnosed”, but equally present in every earlier stage of human history. Consider, though, the discovery of SSRIs, a class of drugs that combined lifetime use with a better safety profile than earlier antidepressants (just weight gain, sexual dysfunction, and the occasional suicide upon withdrawal). And consider the context of that discovery: a world where pharmaceutical companies fund much of the research used in their own regulation, and that research is easy to skew. In short, it is a truth universally acknowledged that a pharmaceutical company in possession of a new drug shall be in want of an endemic illness. As the GlaxoSmithKline slogan bluntly went: “Does your soul have a cold?”
Still, it would be sophomoric to think that depression was wholly and solely constructed by Big Pharma. Until recently, it was understood that “no man living is free, no stoic, none so wise, none so happy, none so patient, so generous, so godly, so divine, that can vindicate himself; so well composed, but more or less, some time or other he feels the smart of” melancholy. So wrote Robert Burton, a reclusive life-long fellow of Oxford, four centuries ago, in his freewheeling account of sadness, The Anatomy of Melancholy.
Burton was writing in one of the last periods where the role of the writer wasn’t to express an individual thesis, but instead to summarise everything. As such, his Anatomy has little in the way of synthetic thought. As Burton says, “I have read many Bookes, but to little purpose, for want of good method, I have confusedly tumbled over divers Authors in our Libraries, with small profit, for want of Art, Order, Memory, Judgment.” He can’t even settle on a definition of melancholy — “whether it be a cause or an effect, a disease or symptom … I will not contend about it” — but he does examine some potential causes. Black bread, melons, hot air, cold air, excessive exercise, defective exercise, the stars, God, hot baths, a hot brain, Calvinism, Catholicism, excessive studying, excessive merrymaking, excessive “chamber-making”.
As for melancholy’s symptoms, “the tower of Babel never yielded such confusion of tongues, as the chaos of melancholy doth variety of symptoms”. Indeed, it’s sometimes difficult to separate cause from symptom, as in the glorious description “lascivious by reason of much wind”. Burton’s aim is to “adventure yet in such vast confusion and generality to bring them into some order; and so descend into particulars”. Many of these loopy excursions come to a familiar enough conclusion: melancholy’s cause is sin, and its cure is God: “We ought to fear our own fickle estates, remember our miseries and vanities, examine and humiliate ourselves, seek to God, and call to Him for mercy.”
But Burton does not deny the importance of strategies to combat melancholia. These include behavioural changes — drink a glass of water upon waking; seek hills or mountains; “be not solitary, be not idle” — and mental ones — avoid prolonging passionate thoughts; avoid believing in predestination; “be meek, merciful, and patient”. There is comfort here, for the post-modern reader. Thanks to the rapid rise of neuroscience and the branding of depression as a “brain disease”, many third-party carriers reimburse doctors for medication management only, and many depressed people are simply handed a prescription by a general practitioner and told to check in in six weeks. In Burton’s day, the old Galenic system of humours did emphasise the physical. But these days depression is treated like heartburn; in more exploring reaches, it’s treated by impersonal, one-size-fits-all cognitive behavioural therapy, now the province of therapy apps advertised by Instagram scroll.
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