
A well-worn and tear-soaked origin story, vaguely reminiscent of biblical incarnation, tends to accompany press reporting on new fertility ventures. Once upon a time there was an ordinary Californian woman with great LinkedIn connections who was trying for some particular goal in the reproductive cycle but failing. Next, after a suitable period of baffled incomprehension at the limits life suddenly had placed upon her, she had the stunning realisation that her experience was shared by many others too. And lo, the idea for a particular new innovation was conceived! Lots of doors were closed in her face as she tried to find a home for her germinating idea, but eventually she overcame the odds, and gave birth to a bouncing biotech start-up.
Recent weeks have brought us two new and impressive examples of this genre. A New Yorker long read about the project of growing a near-identical breast milk substitute from human mammary cells relates the touching tale of Leila Strickland, a cell biologist at Stanford whose personal struggles with breastfeeding led to the formation of her company Biomilq. And within the pages of the Financial Times, we encountered Nicole Shanahan, ex-wife of Google co-founder Sergey Brin and CEO of an intellectual property software company in Silicon Valley. At the age of 31, Shanahan was having difficulties harvesting her eggs in order to freeze them for a future conception — the updated version of “was trying to have a baby but couldn’t”.
In a description that would sound impossibly neurotic were it not being uttered about someone with massive personal wealth, readers are told that she “was haunted by the fear that her life was being shaped by an organ that had been ageing before she was born” (namely, her ovaries). Attending a gathering in the home of a “Hollywood power couple” in 2017 and listening to a talk about the project of scientifically increasing human longevity, she idly swipes open her fertility tracking app and has “a moment of powerful insight”: why is nobody working on “reproductive longevity”? Or, in other words, how can we stop ovaries ageing so fast?
Several years later, and post-divorce from the Google bloke after an alleged (but denied) tryst with Elon Musk, the entrepreneur is still bankrolling academic research into this question on an epic scale. One study she funds is apparently looking at the potential of immunosuppressant drugs currently licensed for organ-transplant patients to delay menopause — if nothing else, a pleasingly symmetrical companion to the prescription of terrifying-sounding off-label drugs to delay puberty at the other end of things.
For some, it will be quite hard to get behind the supposed drama and nobility of Shanahan’s quest — to see her as we are implicitly encouraged to do, as a kind of brave pioneer or astronaut, wandering about in a mostly unknown realm — because this requires us to act like we don’t already know the answers to the questions she asks so urgently. As listed by the FT, these include: “Why are the ovaries one of the first organs to age? Why does the quantity and quality of eggs fall so dramatically? Why do humans go through menopause when so many animals do not?”
The truth is that evolution and natural selection have quite straightforward explanations; in fact, from that perspective, a much more puzzling question is why human females don’t die immediately after menopause, as so many other animals do. But then you realise that Shanahan and her researchers are totally uninterested in any answer that might position the female body as part of the natural world. When they ask “why…?”, all they really want to know is what mechanisms and environments immediately cause the limited shelf-life of human ovaries, so that they can then try to fiddle about with the process.
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